Short term supplementation of creatine monohydrate has been shown to significantly increase muscular performance. It may help athletes work out at a higher intensity during resistance exercise. A resulting greater training stimulus over time may result in enhanced physiologic adaptations. In the body, creatine helps to regenerate ADP (spent energy) back into ATP for increased energy output involving short, intense bursts of energy. Creatine is a natural substance that is synthesized in the body from three amino acids, arginine, glycine and methionine. It is also found naturally in certain foods.