What Is Cissus quadrangularis Extract Cissus quadrangularis extract is a perennial plant in the grape family that is commonly known as adamant creeper, devil's backbone, veldt grape, and asthisamharaka. It is native to the tropical regions of Asia and Africa and has been used for thousands of years for its health benefits. Cissus quadrangularis Benefits Cissus quadrangularis boasts many health benefits but is most well-known for its anti-inflammatory properties. It may aid in reducing swelling and irritations in the body and support the joints and bones.* Cissus quadrangularis may help support healthy eyes and is also loaded with antioxidants and vitamin C, which may help support immune function.* When taken in conjunction with a healthy diet and exercise, Cissus quadrangularis may aid in maintaining healthy body weight, maintaining healthy cholesterol levels, and supporting heart and cardiovascular health.*