Cissus Quadrangularis Extract has been shown to offer a number of benefits including improved joint health, increased bone strength, and possibly weight loss. Our Cissus Super Extract contains 100 capsules at a 1,000mg serving size of two capsules. Studies have shown that anywhere from 500mg 2,000mg taken daily is safe and may offer many benefits such as reduced joint pain and improved bone strength. Our cissus supplement is manufactured in the USA (Eaglewood, New York) and tested in the USA by a cGMP facility. CONSULT YOUR PHYSICIAN BEFORE USE: Known side effects of Cissus Extract include (but are not limited to) drowsiness, dizziness, heartburn, nausea, stomach pains, intestinal gas, dry mouth, headaches, anxiety, insomnia, nightmares. ALLERGEN NOTICE: Contains Rice Flour and may cause skin irritation, redness, or rashes. Do not take if you are on other medications without approval from your physician. STOP USE immediately if any side effects occur and consult with your physician.