Doctor's Best Hesperidin Methyl Chalcone, Vegetarian, 500 mg, 60 Veggie Caps

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Doctor's Best Hesperidin Methyl Chalcone, Vegetarian, 500 mg, 60 Veggie Caps

  • Hesperidin is a powerful neutralizer of free radicals
  • The potent antioxidant activity of hesperidin and metabolic products derived from it, is one ly basis for its structural support of the capillaries and other small blood vessels
  • Best hesperidin methyl chalcone, sourced from Spain, is a flavonoid derived from citrus fruits that many experts believe has synergistic activity with vitamin C
  • Vegetarian
  • Label images may vary

Best hesperidin methyl chalcone, obtained from a quality source in Spain, is a methylated derivative of the bioflavonoid hesperidin. Hesperidin occurs in citrus fruits, particularly sweet oranges, tangerines and lemons, often in association with vitamin C. It was first discovered in 1827, but gained more attention in 1936 when the famed researcher Albert Szent-Gyorgyi reported that bioflavonoids contributed to lessening the circulatory problems associated with scurvy, a condition that results from vitamin C deficiency. After scientific investigations revealed that a crude extract of vitamin C was able to relieve symptoms that purified vitamin C could not, bioflavonoids in citrus were found to work synergistically with vitamin C. Among these citrus bioflavonoids, hesperidin is prominent in helping vitamin C to improve capillary strength, to such an extent that for many years it was termed vitamin P. In 1947, the methyl chalcone form was found to be more bioactive than native hesperidin and to work synergistically with vitamin C.

Antioxidant Support for Circulatory Health*

Hesperidin is a powerful neutralizer of free radicals. In cell culture experiments, hesperidin provided strong protection against agents that could cause cell damage via the production of superoxide and hydroxyl free radicals from oxygen.4 The potent antioxidant activity of hesperidin, and/or metabolic products derived from it, is one ly basis for its structural support of the capillaries and other small blood vessels.5

Supports Vascular Integrity and Capillary Strength*

Reports dating from the 1930s indicate that hesperidin supports blood capillaries by increasing capillary wall tone.1 Hesperidin methyl chalcone in combination with vitamin C was shown to regulate hyaluronidase (an enzyme that breaks down hyaluronic acid), thereby helping to support the integrity of capillary walls.3

Maintenance of the blood vessel endothelium (the one cell thick layer that lines the blood vessel on the inside) is critical for the health of the circulatory system. Among the many functions of these endothelial cells is to control blood vessel tone and help regulate blood flow to organs. In a randomized, double-blind, placebo-controlled trial of 28 individuals with Metabolic Syndrome (this syndrome is not a disease, but rather a cluster of health factors important to watch), participants were given either 500 mg hesperidin or placebo capsules containing cellulose every day for 3 weeks.6 Endothelial function was assessed by measuring flow-mediated dilation (FMD) in the brachial artery. Compared to placebo, participants taking hesperidin had significantly superior FMD after 3 weeks of supplementation.

Additionally, these researchers reported results from a cell culture study they performed to investigate potential mechanisms that might explain the results seen in the clinical trial.6 Treatment of the cells with hesperidin caused enzymes such as nitric oxide synthase to produce nitric oxide, a key molecular messenger for maintenance of healthy vascular function. This experiment is particularly instructive because the effective concentration of hesperidin on these cells can ly be achieved in the body by consuming a 500 mg daily dose of hesperidin.

Hesperidin also produced circulatory benefits in a clinical trial with 24 healthy, middle-aged, moderately overweight men.7

This randomized, placebo-controlled trial monitored the capacity of the blood vessel endothelium to manage relaxation of the vessel wall. Blood pressure was recorded at the beginning and end of each 4-week period. Hesperidin significantly helped participants maintain healthy blood pressure levels in the normal range.

In an extension of this clinical study, the researchers sought evidence that hesperidin may act at the level of the genes. Ten of the original 24 male subjects donated white blood were studied for changes in gene activity due to hesperidin.8 A total 1,819 genes were found to be regulated by hesperidin, and the pattern of the changes in gene expressionsuch as in the areas of cell communications, immune response, and lipid metabolismcould be considered as supporting healthy blood vessels. This study was groundbreaking in that it links hesperidin intake to favorable effects on gene functions.

In another area of circulatory health, an animal model suggests that hesperidin may support healthy eyes by promoting ocular blood flow (delivering nutrients and oxygen to the eyes). Hesperidin was shown to increase blood flow to the iris, ciliary body, and choroid parts of the eye in rabbits.9

Hesperidin also offers the potential to support brain health. Experimental cell research demonstrated that hesperidin protected nerve cells against oxidative damage.10 The relatively low concentration of hesperidin used in this study can ly be attained in the body by taking hesperidin supplements. Other studies have suggested that hesperidin can cross the blood-brain barrier, an important requirement

for bioactive compounds to potentially support brain cells. 11, 12

Hesperidin Methyl Chalcone from Doctors Best offers a powerful citrus flavonoid in a highly absorbable form, with a long history of research that suggests diverse benefits for circulatory health.


1. Garg A, Garg S, Zaneveld LJ, Singla AK. Phytother Res 2001;15:655-69.

2. Zilva SS. Biochem J 1937;31:915-9.

3. Beiler JM, Martin GJ. J Biol Chem 1947;171:507-11.

4. Wilmsen PK, Spada DS, Salvador M. J Agric Food Chem 2005;53:4757-61.

5. Manthey JA, Grohmann K, Guthrie N. Curr Med Chem 2001;8: 135-53.

6. Rizza S, Muniyappa R, Iantorno M, others. J Clin Endocrinol Metab 2011;96:E782-92.

7. Morand C, Dubray C, Milenkovic D, others. Am J Clin Nutr 2011;93:73-80.

8. Milenkovic D, Deval C, Dubray C, others. PLoS One 2011;6:e26669.

9. Liu SX, Chiang CH, Yao QS, Chiou GC. J Ocul Pharmacol Ther 1996;12:95-101.

10. Hwang SL, Yen GC. J Agric Food Chem 2008;56:859-64.

11. Dimpfel W. J Pharm Pharmacol 2006;58:375-9.

12. Youdim KA, Dobbie MS, Kuhnle G, others. J Neurochem 2003;85:180-92.

  • Brand: Doctor's Best
  • Allergen Information: Gluten Free
  • Age Range (Description): Adult
  • Item Form: Capsule
  • Material Feature: Vegetarian
  • Unit Count: 60 Count
  • Item Weight: 0.15 Pounds

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